Biopharmaceutics and clinical pharmacokinetics /
Gibaldi, Milo
Biopharmaceutics and clinical pharmacokinetics / Milo Gibaldi - Fourth edition. - Philadelphia, Pennsylvania : Lea & Febiger, c1991 - x, 406 pages : illustrations ; 27 cm.
Includes bibliographical references and index.
Introduction to pharmacokinetics -- Compartmental and noncompartmental pharmacokinetics -- Gastrointestinal absorption--biologic considerations -- Gastrointestinal absorption--physicohemical considerations -- Gastrointestinal absorption--role of the dosage forms -- Nonoral medication -- Prolonged-release medication -- Bioavailability -- Drug concentration and clinical response -- Drug disposition--distribution -- Drug disposition--elimination -- Pharmacokinetic variability-- body weight, age, sex, and generic factors -- Pharmacokinetic variability--disease -- Pharmacokinetic variability--drug interactions -- Individualization and optimization of drug dosing regiments
This updated introduction to the clinical applications of pharmacokinetics looks at gastrointestinal absorption, prolonged release medication, and drug disposition. The effects of disease, weight, age, sex and genetic factors on pharmacokinetic variability and drug response are detailed. Bioequivalence and regulatory considerations for generic drug.
812113462
BIOPHARMACEUTICS
RM 301.4 .G53 1991
Biopharmaceutics and clinical pharmacokinetics / Milo Gibaldi - Fourth edition. - Philadelphia, Pennsylvania : Lea & Febiger, c1991 - x, 406 pages : illustrations ; 27 cm.
Includes bibliographical references and index.
Introduction to pharmacokinetics -- Compartmental and noncompartmental pharmacokinetics -- Gastrointestinal absorption--biologic considerations -- Gastrointestinal absorption--physicohemical considerations -- Gastrointestinal absorption--role of the dosage forms -- Nonoral medication -- Prolonged-release medication -- Bioavailability -- Drug concentration and clinical response -- Drug disposition--distribution -- Drug disposition--elimination -- Pharmacokinetic variability-- body weight, age, sex, and generic factors -- Pharmacokinetic variability--disease -- Pharmacokinetic variability--drug interactions -- Individualization and optimization of drug dosing regiments
This updated introduction to the clinical applications of pharmacokinetics looks at gastrointestinal absorption, prolonged release medication, and drug disposition. The effects of disease, weight, age, sex and genetic factors on pharmacokinetic variability and drug response are detailed. Bioequivalence and regulatory considerations for generic drug.
812113462
BIOPHARMACEUTICS
RM 301.4 .G53 1991