000			01926nam a2200241Ia 4500
003			NULRC
005			20250520094920.0
008			250520s9999 xx 000 0 und d
020			_a838502784
040			_cNULRC
050			_aRM 301.4 .S53 1999
100			_aShargel, Leon, 1941- _eauthor
245		0	_aApplied biopharmaceutics & pharmacokinetics / _cLeon Shargel and Andrew B. C. Yu
250			_aFourth edition..
260			_a[Place of publication not identifed] : _bPrentice-Hall International Inc., _cc1999
300			_axiv, 768 pages : _billustrations ; _c26 cm.
504			_aIncludes index.
505			_aMathematical fundamentals on pharmacokinetics -- introduction to biopharmaceutics and pharmacokinetics -- one compartment model; physiological factors relating to drug absorption -- biopharmaceutic considerations in drug product design -- modified release drug products -- delivery of biotechnical products and targetted drug delivery systems -- pharmacokinetics of drug absorption -- bioavailability and bioequivalence -- multicompartmental models -- drug distribution and protein binding -- drug clearance; drug metabolism and hepatic clearance -- pharmacokinetics after intravenous infusion -- pharmacokinetics after multiple dosing -- non-linear pharmacokinetics -- introduction to clinical pharmacokinetics -- application of pharmacokinetics to clinical situations -- relationship between pharmacokinetic parameters and pharmacologic response -- physiologic pharmacokinetic model and statistical moment -- computer applications in pharmacokinetics -- biopharmaceutics and pharmacokinetic studies in drug development
520			_aThis work emphasizes the application and understanding of core areas involving bioavailability, population pharmacokinetics, pharmacodynamics, metabolism and drug delivery.
650			_aBIOPHARMACEUTICS
700			_aYu, Andrew B. C. _eco-author
942			_2lcc _cBK
999			_c6134 _d6134