000			02147nam a2200253Ia 4500
003			NULRC
005			20250520094808.0
008			250520s9999 xx 000 0 und d
020			_a9780781750097
040			_cNULRC
050			_aRM 301.5 .R69 2011
100			_aRowland, Malcolm _eauthor
245		0	_aClinical pharmacokinetics and pharmacodynamics : _bconcepts and applications / _cMalcolm Rowland and Thomas N. Tozer
250			_aFourth edition.
260			_aPhiladelphia, Pennsylvania : _bWolters Kluwer Health/Lippincott Williams & Wilkins, _cc2011
300			_axxii, 839 pages : _bcolor illustrations ; _c26 cm.
365			_bUSD4710
504			_aIncludes index.
505			_aTherapeutic relevance -- Fundamental concepts and terminology -- Kinetics following an intravenous bolus dose -- Membranes and distribution -- Elimination -- Kinetics following an extravascular dose -- Absorption -- Response following a single dose -- Therapeutic window -- Constant-rate input -- Multiple-dose regimens -- Variability -- Genetics -- Age, weight, and gender -- Disease -- Nonlinearities -- Drug interactions -- Initiating and managing therapy -- Distribution kinetics -- Metabolites and drug response -- Protein drugs -- Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data
520			_a"Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject."--Jacket
650			_aPHARMACOKINETICS
700			_aTozer Thomas N. _eco-author
942			_2lcc _cBK
999			_c2796 _d2796