000			01755nam a2200241Ia 4500
003			NULRC
005			20250520102922.0
008			250520s9999 xx 000 0 und d
020			_a9781585286010
040			_cNULRC
050			_aRS 403 .H37 2018
100			_aHarrold, Marc W. _eauthor
245		0	_aBasic concepts in medicinal chemistry / _cMarc W. Harrold
250			_aSecond edition.
260			_aBethesda, Maryland : _bAmerican Society of Civil Engineers, _cc2018
300			_axii, 606 pages : _billustrations ; _c26 cm.
365			_bUSD63
504			_aIncludes index.
505			_aFunctional group characteristics and roles -- Identifying acidic and basic functional groups -- Solving pH and pKa problems -- Salts and solubility -- Drug binding interactions -- Stereochemistry and drug action -- Drug metabolism -- Structure activity relationships and basic concepts in drug design -- Whole molecule drug evaluation
520			_aMedicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.
650			_aPHARMACEUTICAL CHEMISTRY
942			_2lcc _cBK
999			_c18770 _d18770