000			02182nam a2200229Ia 4500
003			NULRC
005			20250520102922.0
008			250520s9999 xx 000 0 und d
020			_a9780124115088
040			_cNULRC
050			_aRM 301.25 .B53 2015
100			_aBlass, Benjamin E. _eauthor
245		0	_aBasic principles of drug discovery and development / _cBenjamin E. Blass
260			_aAmsterdam : _bElsevier/AP, _cc2015
300			_axv, 574 pages : _billustrations ; _c23 cm
365			_bUSD88.7
504			_aIncludes index.
505			_aDrug discovery and development : an overview of modern methods and principles -- The Crug discovery process : from ancient times to the present day -- Classical targets in drug discovery -- In vitro screenign systems -- Medicinal chemistry -- In vitro ADME and in vivo pharmacokinetics -- Animal models of disease states -- Safety and toxicology -- Basics of clinical trials -- Translational medicine and biomarkers -- Organizational considerations and trends in the pharmaceutical industry -- Intellectual property and parents in drug discovery -- Case studeis in drug discovery
520			_aBasic Principles of Drug Discovery and Development presents the multifaceted process of identifying a new drug in the modern era, providing comprehensive explanations of enabling technologies such as high throughput screening, structure based drug design, molecular modeling, pharmaceutical profiling, and translational medicine, all areas that have become critical steps in the successful development of marketable therapeutics. The text introduces the fundamental principles of drug discovery and development, also discussing important drug targets by class, in vitro screening methods, medicinal chemistry strategies in drug design, principles in pharmacokinetics and pharmacodynamics, animal models of disease states, clinical trial basics, and selected business aspects of the drug discovery process. It is designed to enable new scientists to rapidly understand the key fundamentals of drug discovery, including pharmacokinetics, toxicology, and intellectual property."
650			_aDRUGS -- DESIGN
942			_2lcc _cBK
999			_c18769 _d18769