000			02083nam a2200241Ia 4500
003			NULRC
005			20250520102922.0
008			250520s9999 xx 000 0 und d
020			_a9780702042997
040			_cNULRC
050			_aRM 301.25 .D78 2013
245		0	_aDrug discovery and development / _cedited by Raymond Hill and Humphrey Rang
250			_aSecond edition.
260			_aEdinburg, New York : _bElsevier Science, _cc2013
300			_axiv, 345 pages : _billustrations ; _c25 cm
365			_bUSD59.98
504			_aIncludes bibliographical references and index.
505			_aIntroduction and background -- Drug discovery -- Drug development -- Facts and figures
520			_aThe modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market.
650			_aPHARMACEUTICAL INDUSTRY
700			_aHill, Raymond;Rang, Humphrey _eeditor;editor
942			_2lcc _cBK
999			_c18754 _d18754