000			02043nam a2200241Ia 4500
003			NULRC
005			20250520102922.0
008			250520s9999 xx 000 0 und d
020			_a127444815
040			_cNULRC
050			_aRS 403 .P73 2015
245		4	_aThe practice of medicinal chemistry / _cedited by Camille G. Wermuth [and three others].
250			_aFourth edition.
260			_aAmsterdam : _bElsevier Science, _cc2015
300			_axxii, 880 pages : _bcolor illustrations ; _c29 cm.
365			_bUSD150
504			_aIncludes index.
505			_aGeneral aspects of medicinal chemistry -- Lead compound discovery strategies -- Primary exploration of structure-activity relationships -- Substituents and functions: qualitative aspects of structure-activity relationships -- Spatial organization, recepor mapping and molecular modeling -- Chemical modifications influencing the pharmacokinetic properties -- Pharmaceutical and chemical means to solubility and formulation problems
520			_aThe Practice of Medicinal Chemistry, 2E, is a single-volume source on the practical aspects of medicinal chemistry. The successful first edition was nicknamed "The Bible" by medicinal chemists, and the second edition has been updated, expanded and refocused to reflect developments over the last decade. Emphasis is put on how medicinal chemists conduct their search for and design of new drug entities. In contrast to competing books, it focuses on the chemistry rather than pharmacological concepts or descriptions of the various therapeutic classes of drugs. Most medicinal chemists working in the pharmaceutical industry are organic synthetic chemists who must acquire a strong knowledge of medicinal chemistry as they enter the industry. This book aims to be their practical handbook - a complete guide to the drug discovery process.
650			_aPHARMACEUTICAL CHEMISTRY
700			_aWermuth, Camille Georges;Aldous, David;Raboisson, Pierre;Rognan, Didier _eeditor;co-editor;co-editor;co-editor
942			_2lcc _cBK
999			_c18745 _d18745