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020 _a9781439891674
040 _cNULRC
050 _aQP 517.B44 .C44 2013
245 0 _aChemistry and pharmacology of naturally occurring bioactive compounds /
_cedited by Goutam Brahmachari.
260 _aBoca Raton, Florida :
_bCRC Press,
_cc2013
300 _axxii, 550 pages :
_billustrations ;
_c26 cm.
365 _bUSD9458.00
505 _aCh. 1. Chemistry and pharmacology of naturally occurring bioactive compounds : an overview / Goutam Brahmachari -- ch. 2. Impact of solid-supported cyclization-elimination strategies toward the development of natural product inspired molecules in drug discovery research / Dhananjay Kumar [and others] -- ch. 3. Synthesis and biological studies of novel B-Lactams / Bimal K. Banik -- ch. 4. Applications of isatin chemistry in organic synthesis and medicinal chemistry / Girija S. Singh and Zelalem Y. Desta -- ch. 5. Role of organic carbamates in anticancer drug design / Devdutt Chaturvedi -- ch. 6. Rational design of new molecules of biological significance from phenolic constituents of some tropical plants as renewable materials / Vladimir V. Kouznetsov [and others] -- ch. 7. Synthesis and biological activity of promising azole marine products: largazole and neopeltolide / Danilo Davyt and Gloria Serra -- ch. 8. Omega-3 (o-3) polyunsaturated fatty acids / Philip C. Calder -- ch. 9. Structure and biological activity of natural melanin pigments / Krystyna Ste̜pień [and others] -- ch. 10. Recent acquisitions on naturally occurring oxyprenylated secondary plant metabolites / Francesco Epifano and Salvatore Genovese -- ch. 11. Role of curcumin in ameliorating neuroinflammation and neurodegeneration associated with Alzheimer's disease / Sumit Sarkar [and others] -- ch. 12. Plant metabolites : inhibitors of NO production / Marina P. Polovinka and Nariman F. Salakhutdinov -- ch. 13. X-ray structural behavior of some significant bioactive steroids and their chemistry in the crystal packing and related matters / Vivek K. Gupta -- ch. 14. Three-dimensional structure of Xanthones / Lus̕ Gales and Ana M. Damas -- ch. 15. Gambogic acid : a caged prenylated garcinia xanthone: potent anticancer agent of pharmaceutical promise / Goutam Brahmachari -- ch. 16. Neuroplasticity as a new approach to the pathophysiology of depression and the role of antidepressants in inhibiting brain stress-induced changes in brain activity / Gianluca Serafini, Maurizio Pompili, and Paolo Girardi -- ch. 17. Statins : fermentation products for cholesterol control in humans / Vincent Gullo and Arnold L. Demain -- ch. 18. Molecular aspects of fungal bioactive polyketides / Ira Bhatnagar and Se-Kwon Kim -- ch. 19. Marine microalgal metabolites : a promising source of pharmaceuticals / S.W.A. Himaya and Se-Kwon Kim -- ch. 20. Rosmarinic acid : biological, pharmacological, and in vitro plant cell culture approximation / Juan C. Luis [and others] -- ch. 21. Enhancement of natural antioxidants in plants by biosynthetic pathway modulation / Kanakapura K. Namitha and Pradeep S. Negi -- ch. 22. Plant as biofactories of pharmaceuticals and nutraceuticals / Dandara R. Muniz [and others]. Chemistry and pharmacology of naturally occurring bioactive compounds : an overview / Goutam Brahmachari -- Impact of solid-supported cyclization-elimination strategies toward the development of natural product inspired molecules in drug discovery research / Dhananjay Kumar, Bhuwan B. Mishra, Divya Kushwaha, and Vinod K. Tiwari -- Synthesis and biological studies of novel ß-lactams / Bimal K. Banik -- Applications of isatin chemistry in organic synthesis and medicinal chemistry / Girija S. Singh and Zelalem Y. Desta -- Role of organic carbamates in anticancer drug design / Devdutt Chaturvedi -- Rational design of new molecules of biological significance from phenolic constituents of some tropical plants as renewable materials / Vladimir V. Kouznetsov, Diego R. Merchan Arenas, Fernando A. Rojas Ruiz, and Leonor Y. Vargas Méndez -- Synthesis and biological activity of promising azole marine products : largazole and neopeltolide / Danilo Davyt and Gloria Serra -- Omega-3 (ω-3) polyunsaturated fatty acids / Philip C. Calder -- Structure and biological activity of natural melanin pigments / Krystyna Ste̜pień, Anna Dzierże̜ga-Le̜cznar, Irena Tam, and Slawomir Kurkiewicz -- Recent acquisitions on naturally occurring oxyprenylated secondary plant metabolites / Francesco Epifano and Salvatore Genovese -- Role of curcumin in ameliorating neuroinflammation and neurodegeneration associated with Alzheimer's disease / Sumit Sarkar, Balmiki Ray, Jay Sharma, Larry Schmued, and Debomoy K. Lahiri -- Plant metabolites : inhibitors of NO production / Marina P. Polovinka and Nariman F. Salakhutdinov -- X-ray structural behavior of some significant bioactive steroids and their chemistry in the crystal packing and related matters / Vivek K. Gupta -- Three-dimensional structure of xanthones / Luís Gales and Ana M. Damas -- Gambogic acid : a caged prenylated Garcinia xanthone : potent anticancer agent of pharmaceutical promise / Goutam Brahmachari -- Neuroplasticity as a new approach to the pathophysiology of depression and the role of antidepressants in inhibiting brain stress-induced changes in brain activity / Gianluca Serafini, Maurizio Pompili, and Paolo Girardi -- Statins : fermentation products for cholesterol control in humans / Vincent Gullo and Arnold L. Demain -- Molecular aspects of fungal bioactive polyketides / Ira Bhatnagar and Se-Kwon Kim -- Marine microalgal metabolites : a promising source of pharmaceuticals / S.W.A. Himaya and Se-Kwon Kim -- Rosmarinic acid : biological, pharmacological, and In vitro plant cell culture approximation / Juan C. Luis, Maria Y. González-Padrón, Raquel M. Pérez, Ignacio F. Viera, and Francisco V. González -- Enhancement of natural antioxidants in plants by biosynthetic pathway modulation / Kanakapura K. Namitha and Pradeep S. Negi -- Plant as biofactories of pharmaceuticals and nutraceuticals / Dandara R. Muniz, Raquel O. Faria, Vagner A. Benedito, Ângelo de Fátima, and Luzia V. Modolo.
520 _aNatural products play crucial roles in modern drug development, and constitute a prolific source of novel lead compounds or pharmacophores for ongoing drug discovery programs. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds presents cutting-edge research in the chemistry of bioactive natural products and demonstrates how natural product research continues to make significant contributions in the discovery and development of new medicinal entities. In 21 chapters, this book highlights chemistry and pharmaceutical potential of natural products in modern drug discovery processes, and covers the synthesis and semi-synthesis of potentially bioactive natural products. Written for phytochemists, synthetic chemists, combinatorial chemists, as well as other practitioners and students in related fields, the book features chemical advances in naturally occurring organic compounds and describes their chemical transformations and structure–activity relationships.
650 _aNATURAL PRODUCTS
942 _2lcc
_cBK
999 _c13297
_d13297