000			02061nam a2200253Ia 4500
003			NULRC
005			20250520100653.0
008			250520s9999 xx 000 0 und d
020			_a9781259071409
040			_cNULRC
050			_aRM 301.4 .S53 2012
100			_aShargel, Leon _eauthor
245		0	_aApplied biopharmaceutics and pharmacokinetics / _cShargel Leon, Susanna Wu-Pong, and Andrew B.C. Yu
250			_aSixth edition.
260			_aNew Jersey : _bMcGraw Hill Education, _cc2012
300			_avii, 811 pages : _billustrations ; _c23 cm.
365			_bPHP2338
504			_aIncludes bibliographical references and index.
505			_aIntroduction to Biopharmaceutics and Pharmacokinetics -- Mathematical Fundamentals in Pharmacokinetics -- One-Compartment Open Model: Intravenous Bolus Administration -- Multicompartment Models: Intravenous Bolus Administration -- Intravenous Infusion -- Drug Elimination and Clearance -- Pharmacokinetics of Oral Absorption -- Multiple-Dosage Regimens -- Nonlinear Pharmacokinetics -- Physiologic Drug Distribution and Protein Binding -- Drug Elimination and Hepatic Clearance -- Pharmacogenetics -- Physiologic Factors Related to Drug Absorption -- Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance -- Drug Product Performance, In Vivo: Bioavailability and Bioequivalence -- Impact of Drug Product Quality and Biopharmaceutics on Clinical Efficacy -- Modified-Release Drug Products -- Targeted Drug delivery Systems and Biotechnological Products -- Relationship Between Pharmacokinetics and Pharmacodynamics -- Application of Pharmacokinetics to Clinical Situations -- Dose Adjustment in Renal and Hepatic -- Physiologic Pharmacokinetic Models, Mean Residence Time, and Statistical Moment Theory
520			_aThis text integrates basic scientific principles with drug product development and clinical pharmacy practice.
650			_aBIOPHARMACEUTICS -- PHARMACOKINETICS
700			_aWu-Pong, Susanna;Yu, Andrew B.C _eco-author;co-author
942			_2lcc _cBK
999			_c10975 _d10975