000			01519nam a2200229Ia 4500
003			NULRC
005			20250520100640.0
008			250520s9999 xx 000 0 und d
020			_a838502067
040			_cNULRC
050			_aRM 301.4 .S53 1980
100			_aShargel, Leon. _eauthor
245		0	_aApplied biopharmaceutics and pharmacokinetics / _cLeon Shargel and Andrew B. C. Yu.
260			_aNew York : _bAppleton-Century-Crofts, _cc1980
300			_avii, 245 pages ; _c24 cm.
504			_aIncludes bibliographical references and index.
505			_a1. Review of mathematical fundamentals -- 2. Rates and orders of reactions -- 3. Introduction to pharmacokinetics -- 4. One-compartment open model -- 5. Multicompartment models -- 6. Biopharmaceutic aspects of drug products -- 7. Pharmacokinetics of drug absorption -- 8. Bioavailability and bioequivalence -- 9. Drug clearance -- 10. Hepatic elimination of drugs -- 11. Protein binding of drugs -- 12. Intravenous infusion -- 13. Multiple dosage regimens -- 14. Nonlinear pharmacokinetics -- 15. Application of pharmacokinetics in clinical situations -- 16. Dosage adjustment in renal disease -- 17. Relationship between pharmacokinetic parameters and pharmacologic response.
520			_aThe main objective of this book is to present basic concepts in practical biopharmaceutics and pharmacokinetics to students with at least a minimal skill in mathematics.
650			_aBIOPHARMACEUTIC
700			_aYu, Andrew B. C. _eco-author
942			_2lcc _cBK
999			_c10403 _d10403