Shargel, Leon, 1941- <br/><br/>
Applied biopharmaceutics & pharmacokinetics / 
Leon Shargel and  Andrew B. C. Yu 
 - Fourth edition.. 
 - [Place of publication not identifed] :  Prentice-Hall International Inc.,  c1999 
 - xiv, 768 pages :  illustrations ;  26 cm. 
<br/><br/>Includes index. 
<br/><br/>Mathematical fundamentals on pharmacokinetics -- introduction to biopharmaceutics and pharmacokinetics -- one compartment model; physiological factors relating to drug absorption -- biopharmaceutic considerations in drug product design --  modified release drug products -- delivery of biotechnical products and targetted drug delivery systems -- pharmacokinetics of drug absorption -- bioavailability and bioequivalence -- multicompartmental models -- drug distribution and protein binding -- drug clearance; drug metabolism and hepatic clearance -- pharmacokinetics after intravenous infusion -- pharmacokinetics after multiple dosing -- non-linear pharmacokinetics -- introduction to clinical pharmacokinetics -- application of pharmacokinetics to clinical situations -- relationship between pharmacokinetic parameters and pharmacologic response -- physiologic pharmacokinetic model and statistical moment -- computer applications in pharmacokinetics -- biopharmaceutics and pharmacokinetic studies in drug development 
<br/><br/> This work emphasizes the application and understanding of core areas involving bioavailability, population pharmacokinetics, pharmacodynamics, metabolism and drug delivery. 
<br/><br/><label>ISBN: </label>838502784 
<br/><br/><label>Subjects--Topical Terms: </label><br/>BIOPHARMACEUTICS
<br/><br/><label>LC Class. No.: </label>RM 301.4 .S53 1999