Hospital Pharmacy
- Los Angeles : SAGE, c2022.
- 413-587 pages : illustrations ; 28 cm.
- Hospital Pharmacy, Volume 57, Issue 4, August 2022 .
Includes bibliographical references.
Latex Allergy Alerts in the Age of CPOE: Assessing the Risk From Injectable Medications -- Antimicrobial Stewardship in the Covid-19 Pandemic -- Could Decreased Reporting of Suspected Adverse Reactions Generate Future Safety Concerns? -- Leading Through Rapid Change Management -- Pharmacy Resident Perspectives on the Layered Learning Practice Model -- Formulary Drug Review: Belumosudil -- Impact of Pharmacist Education on Incoming Medical Residents -- Pre-Endoscopy Use of Proton Pump Inhibitor Intravenous Bolus Dosing in Hemodynamically Stable Patients With Suspected Upper Gastrointestinal Bleeding: Results of a Pharmacist-Managed Hospital Protocol to Reduce Continuous Infusion Pantoprazole Use -- Retrospective Indication-Matched Cohort Study of Reference Product and Biosimilar: Bevacizumab Versus Bevacizumab-Awwb -- Risk Factors for Antibiotic Resistant Urinary Pathogens in Patients Discharged From the Emergency Department -- Review of Pharmacist Driven Penicillin Allergy Assessments and Skin Testing: A Multi-Center Case-Series -- Creation of a State Drug Shortage Dashboard in the COVID-19 Pandemic -- Implementation of Daily Pharmacy Student New Medication Education During Hospitalization to Improve Patient Satisfaction -- Ambulatory Care Pharmacist Perception of Formulary Medication Shortage: Tertiary Center Experience -- Impact of Order-Set Modifications and Provider Education Following Guideline Updates on Broad-Spectrum Antibiotic Use in Patients Admitted With Community Acquired Pneumonia -- Evaluation of Unfractionated Heparin Dosing by Antifactor Xa During Targeted Temperature Management Post Cardiac Arrest -- Impact of Stress Ulcer Prophylaxis Discontinuation Guidance in Mechanically Ventilated, Critically Ill Patients: A Pre-Post Cohort Study -- Drug-Drug Interaction Between Orally Administered Hydrocodone-Acetaminophen and Inhalation of Cannabis Smoke: A Case Report -- Automated Dispensing Cabinet Functionality Expansion to Reduce Controlled Substance Inventory Discrepancies -- Assessing Nephrotoxicity Associated With Different Vancomycin Dosing Modalities in Obese Patients at a Community Hospital -- Prophylactic Enoxaparin in Critically Ill Trauma Patients: Evaluation of the Initial Dose -- Comparison of Higher-Than-Standard to D-Dimer Driven Thromboprophylaxis in Hospitalized Patients With COVID-19 -- Blood Pressure Control and Associated Factors Among Hypertensive Patients Attending Shashemene Referral Hospital, Oromia, Ethiopia -- Leukocytoclastic Vasculitis Following COVID-19 Vaccination: A Case Report -- Is Cefoxitin a Carbapenem Sparing Agent in the Management of Urinary Tract Infections Caused by ESBL Producing Enterobacterales? -- Narrative Review: Addressing Covid-19 Vaccine Concerns in Special and Vulnerable Populations.
[Article Title: Latex Allergy Alerts in the Age of CPOE: Assessing the Risk From Injectable Medications/ SErik A. Preheim, Cynthia M. Phillips, and Kyle A. Weant, p. 413-415] https://doi.org/10.1177/00185787211048123 [Article Title: Antimicrobial Stewardship in the Covid-19 Pandemic/ Sergio Venturini, Manuela Avolio, Sara Fossati, Astrid Callegari, Rita De Rosa, Barbara Basso, Chiara Zanusso, Daniele Orso, Francesco Cugini, and Massimo Crapis, p. 416-418]
Abstract: During COVID-19 pandemic, implementing and maintaining an antimicrobial stewardship protocol obtained both low rates of MDR microorganisms and low antimicrobial use in an 800-bed hospital network in northern Italy. Infectious diseases specialist consulting was crucial to maintain this protocol active. https://doi.org/10.1177/00185787221075190 [Article Title: Could Decreased Reporting of Suspected Adverse Reactions Generate Future Safety Concerns?/ Francesco Ferrara, Carolina Mancaniello, Livia Nava, Alessandra Salierno, Raffaele Casillo, Ugo Trama, Eduardo Nava, and Antonio Vitiello, p. 419-421]
Abstract: https://doi.org/10.1177/00185787211069040 [Article Title: Leading Through Rapid Change Management/ Lauren Stanz, Steven Silverstein, Derek Vo, and Jennifer Thompson, p. 422-424] https://doi.org/10.1177/00185787211046855 [Article Title: Pharmacy Resident Perspectives on the Layered Learning Practice Model/ Nathan V. Dang,Tiffany K. Pon, and Yvette M. Hellier, p. 425-434]
Abstract: To describe pharmacy resident perspectives on the layered learning practice model (LLPM) at large academic medical centers in the United States and identify the types of training residents receive to prepare for the LLPM. https://doi.org/10.1177/00185787211066458 [Article Title: Formulary Drug Review: Belumosudil/ Terri L. Levien, and Danial E. Baker, p. 435-441]
Abstract: Each month, subscribers to The Formulary Monograph Service receive 5 to 6 well-documented monographs on drugs that are newly released or are in late phase 3 trials. The monographs are targeted to Pharmacy & Therapeutics Committees. Subscribers also receive monthly 1-page summary monographs on agents that are useful for agendas and pharmacy/nursing in-services. A comprehensive target drug utilization evaluation/medication use evaluation (DUE/MUE) is also provided each month. With a subscription, the monographs are available online to subscribers. Monographs can be customized to meet the needs of a facility. Through the cooperation of The Formulary, Hospital Pharmacy publishes selected reviews in this column. For more information about The Formulary Monograph Service, contact Wolters Kluwer customer service at 866-397-3433. https://doi.org/10.1177/00185787211061381 [Article Title: Impact of Pharmacist Education on Incoming Medical Residents/ Leslie A. Hamilton, Michael L. Behal, and William P. Metheny, p. 442-447]
Abstract: The graduating medical student transitioning to the role of a first-year medical resident is expected to know the proper medications and dosages for routine patient conditions. Pharmacists on an interdisciplinary health care team can be effective teachers of medical residents. Given the small amount of pharmacy-based education included in medical school curricula, it is important that medical residents have a basic foundation of pharmacotherapeutic knowledge. The purpose of this study was to assess the effectiveness of a pharmacist-led education session in improving medical resident pharmacotherapy knowledge. https://doi.org/10.1177/00185787211046860 [Article Title: Pre-Endoscopy Use of Proton Pump Inhibitor Intravenous Bolus Dosing in Hemodynamically Stable Patients With Suspected Upper Gastrointestinal Bleeding: Results of a Pharmacist-Managed Hospital Protocol to Reduce Continuous Infusion Pantoprazole Use/ Andrew C. Faust, Lauren Schwaner, Drew Thomas, Shilpa Sannapanei, and Mark Feldman, p. 448-454]
Abstract: Guidelines for acute upper gastrointestinal bleeding (UGIB) recommend use of proton pump inhibitors (PPI) administered by continuous IV infusion (CI). Although data suggest comparable outcomes with CI and IV push (IVP) dosing post-endoscopy, there are limited data to support IVP PPI as the pre-endoscopy regimen. https://doi.org/10.1177/00185787211046854 [Article Title: Retrospective Indication-Matched Cohort Study of Reference Product and Biosimilar: Bevacizumab Versus Bevacizumab-Awwb/ Jennifer Philippon Booth, and Jeffrey Pilz, p. 455-461]
Abstract: Due to the abbreviated approval pathway and extrapolation to non-studied indications, an increased importance is placed on post-marketing surveillance of biosimilars to supplement existing evidence and enhance patient and provider confidence. Bevacizumab-awwb (ABP 215, Mvasi) was the first biosimilar approved to bevacizumab (Avastin), a recombinant humanized monoclonal IgG1 antibody that inhibits the vascular endothelial growth factor (VEGF). https://doi.org/10.1177/00185787211046865 [Article Title: Risk Factors for Antibiotic Resistant Urinary Pathogens in Patients Discharged From the Emergency Department/ Stephanie L. Barré, Erin R. Weeda, Andrew J. Matuskowitz, Gregory A. Hall, and Kyle A. Weant, p. 462-468]
Abstract: Urinary tract infections (UTIs) are one of the most common indications for antimicrobial use in the emergency department (ED). Appropriate empiric selection is crucial to ensure optimal care while limiting broad-spectrum antibiotic use. The primary objective of this study was to evaluate the relationship between patient-specific risk factors and drug resistant urinary pathogens in patients discharged from the ED and followed by Emergency Medicine Pharmacists (EMPs). https://doi.org/10.1177/00185787211046851 [Article Title: Review of Pharmacist Driven Penicillin Allergy Assessments and Skin Testing: A Multi-Center Case-Series/ Hanna M. Harper, and Michael Sanchez, p. 469-473]
Abstract: To describe the impact of pharmacy driven penicillin allergy assessments on de-labeling penicillin allergies and antibiotic streamlining opportunities for hospitalized patients. Design: Multi-center, retrospective case-series study. https://doi.org/10.1177/00185787211046862 [Article Title: Creation of a State Drug Shortage Dashboard in the COVID-19 Pandemic/ Kristin Lux, Melinda Jorns, and Carrie Vogler, p. 474-481]
Abstract: Drug shortages are anticipated to worsen with time as the Coronavirus Disease 2019 (COVID-19) pandemic continues. The aim of this study is to track drug shortages within Illinois and identify causes and trends to this time-sensitive problem. https://doi.org/10.1177/00185787211046861 [Article Title: Implementation of Daily Pharmacy Student New Medication Education During Hospitalization to Improve Patient Satisfaction/ Alexandra Whiddon Tatara, Christine Ji, Susan Jacob, and John Marshall, p. 482-487]
Abstract: Studies have shown that patients would like to receive more medication education while hospitalized. Higher patient satisfaction has been correlated with lower mortality and fewer hospital readmissions. https://doi.org/10.1177/00185787211051644 [Article Title: Ambulatory Care Pharmacist Perception of Formulary Medication Shortage: Tertiary Center Experience/ Saud Jaser, Kholoud Al Aamer, Abdulaziz Al Anizi, Nargis Begum Javed, and Mohammed AL-Mohaithef, p. 488-495]
Abstract: Medication shortage is a serious issue affecting public health and patient care. It causes a major burden on the medical team of a healthcare organization in the delivery of quality care. Objectives: This study aims to assess the perception of ambulatory care pharmacist about formulary medication shortage as well as to assess the rate of medication shortage and explore the highest classes of the not-available (NA) medication. [Article Title: Impact of Order-Set Modifications and Provider Education Following Guideline Updates on Broad-Spectrum Antibiotic Use in Patients Admitted With Community Acquired Pneumonia/ Jessica L. Colmerauer, Kristin E. Linder, Casey J. Dempsey, Joseph L. Kuti, David P. Nicolau, and Anastasia Bilinskaya, p. 496-503]
Abstract: Following updates to the Infectious Diseases Society of America (IDSA) practice guidelines for the Diagnosis and Treatment of Adults with Community-acquired Pneumonia in 2019, Hartford HealthCare implemented changes to the community acquired pneumonia (CAP) order-set in August 2020 to reflect criteria for the prescribing of broad-spectrum antimicrobial therapy. The objective of the study was to evaluate changes in broad-spectrum antibiotic days of therapy (DOT) following these order-set updates with accompanying provider education. https://doi.org/10.1177/00185787211055797 [Article Title: Evaluation of Unfractionated Heparin Dosing by Antifactor Xa During Targeted Temperature Management Post Cardiac Arrest/ Carrigan Belcher, Vivek Kataria, Klayton M Ryman, Xuan Wang,Joon Yong Moon, Ariel Modrykamien, and Adan Mora, p. 504-509]
Abstract: To evaluate unfractionated heparin (UFH) dosing guided by antifactor Xa levels during targeted temperature management (TTM) post-cardiac arrest. https://doi.org/10.1177/00185787211061383 [Article Title: Impact of Stress Ulcer Prophylaxis Discontinuation Guidance in Mechanically Ventilated, Critically Ill Patients: A Pre-Post Cohort Study/ Christopher A. Jones, Kevin D. Betthauser, Bryan D. Lizza, Paul A. Juang, Scott T. Micek, andMarin H. Kollef, p. 510-517]
Abstract: Recent data highlight unclear efficacy and potential negative sequelae of stress ulcer prophylaxis (SUP) in the intensive care unit (ICU). Minimizing SUP exposure has pertinent clinical and other implications. This study assessed medication use and clinical outcomes before and after implementation of a practice guideline promoting early discontinuation of SUP in mechanically ventilated ICU patients. https://doi.org/10.1177/00185787211061371 [Article Title: Drug-Drug Interaction Between Orally Administered Hydrocodone-Acetaminophen and Inhalation of Cannabis Smoke: A Case Report/ Ross Jason Bindler, Christy J. W. Watson, Abram J. Lyons, Lillian Skeiky, Jamie Lewis, Michael McDonell, Philip Lazarus, and Marian Wilson, p. 518-525]
Abstract: To determine if a 2-day protocol measuring pharmacokinetic and pharmacodynamic characteristics can demonstrate drug-drug interactions when smoked cannabis is added to orally administered hydrocodone/acetaminophen combination products. https://doi.org/10.1177/00185787211061374 [Article Title: Automated Dispensing Cabinet Functionality Expansion to Reduce Controlled Substance Inventory Discrepancies/ James A. M. Rhodes, Bryan C. McCarthy, and Anthony C. Scott, p. 526-531]
Abstract: Automated dispensing cabinets have the potential to create technology-induced errors that can arise during controlled substance medication dispensing. Despite enhancements made to the medication use process, the impact of ADC functionality on technology-induced controlled substance discrepancies have yet to be described. https://doi.org/10.1177/00185787211061380 [Article Title: Assessing Nephrotoxicity Associated With Different Vancomycin Dosing Modalities in Obese Patients at a Community Hospital/ Amanda Wolfe, Jonathan Bowling, Marintha R. Short, Greg Mateyoke, and Steven C. Berger, p. 532-539]
Abstract: Vancomycin requires therapeutic drug monitoring (TDM) based on its pharmacokinetic properties, and guidelines have shifted to analyzing area under the curve over 24 hours (AUC24) rather than trough concentrations due to nephrotoxicity concerns and correlation to efficacy. Obesity is an established risk factor for vancomycin-induced nephrotoxicity due to increased drug exposure based on dosing calculations and volume of distribution estimation. The aim of this study is to assess the relationship between AUC-based versus trough-based dosing and nephrotoxicity among obese patients receiving vancomycin. https://doi.org/10.1177/00185787211055791 [Article Title: Prophylactic Enoxaparin in Critically Ill Trauma Patients: Evaluation of the Initial Dose/ Kaitlyn J. Agedal, Elizabeth A. Feldman, Robert W. Seabury, William Darko, Luke A. Probst, Christopher D. Miller, and Gregory M. Cwikla, p. 540-545]
Abstract: Trauma patients are at increased risk of developing venous thromboembolism given alterations in the coagulation cascade. Chemoprophylaxis with standard dosing of enoxaparin 30 mg subcutaneously twice daily has evolved to incorporate the use of anti-factor Xa (AFXa) trough level monitoring given concerns for decreased enoxaparin bioavailability in this patient population. Current available evidence suggests low rates of goal AFXa trough level achievement with standard enoxaparin dosing. Our study aims to identify the incidence of critically ill trauma patients that did not achieve goal AFXa trough levels and attempts to identify predictors that may influence the lack of achievement of goal levels. https://doi.org/10.1177/00185787211067374 [Article Title: Comparison of Higher-Than-Standard to D-Dimer Driven Thromboprophylaxis in Hospitalized Patients With COVID-19/ Maya R. Chilbert, Collin M. Clark, Ashley E. Woodruff, Kimberly Zammit, Cynthia Lackie, Kristen Kusmierski, Patrick McGrath, Gregory Fuhrer, Anna Augostini, Olivia Denny,Nicole Ross, Marissa Saber, and Natalie DelGuidice, p. 546-554]
Abstract: Coronavirus disease 2019 is a global health threat often accompanied with coagulopathy. Despite use of thromboprophylaxis in this population, thrombotic event rates are high. https://doi.org/10.1177/00185787211066456 [Article Title: Blood Pressure Control and Associated Factors Among Hypertensive Patients Attending Shashemene Referral Hospital, Oromia, Ethiopia/ Aliyi Anota, and Teshome Nedi, p. 555-563]
Abstract: Hypertension is public health challenge worldwide. It is defined as persistently elevated arterial blood pressure (BP), systolic BP (SBP) ≥140 mmHg and/or diastolic BP (DBP) ≥90 mmHg or use of antihypertensive medication in adults older than 18 years. The aim of this study was to assess blood pressure control and associated factors among hypertensive patients attending the outpatient department of Shashemene Referral Hospital. https://doi.org/10.1177/00185787211061372 [Article Title: Leukocytoclastic Vasculitis Following COVID-19 Vaccination: A Case Report/Juny Sebastian, Merrin Mathew, Veeranna Sharsty, and Madhan Ramesh, p. 564-567]
Abstract: Hypersensitivity or Leukocytoclastic vasculitis (LCV) following the COVID-19 vaccination has been reported rarely all over the world. LCV can be induced by certain factors such as infections, autoimmune disorders, malignancy, or some classes of drugs. https://doi.org/10.1177/00185787211067379 [Article Title: Is Cefoxitin a Carbapenem Sparing Agent in the Management of Urinary Tract Infections Caused by ESBL Producing Enterobacterales?/ Wasim S. El Nekidy, Manal M. Abdelsalam, Ahmad R. Nusair, Rania El Lababidi, Ruba Z. Dajani, Terrence J. Lee St. John, and Islam M. Ghazi, p. 568-574]
Abstract: Cefoxitin has shown in vitro activity against Extended-Spectrum β-Lactamase (ESBL) producing Enterobacterales. Outcome data regarding cefoxitin as a carbapenem sparing agent in the management of urinary tract infections (UTI) are scarce. We sought to evaluate the clinical and microbiologic efficacy of cefoxitin as compared to ertapenem. https://doi.org/10.1177/00185787211066460 [Article Title: Narrative Review: Addressing Covid-19 Vaccine Concerns in Special and Vulnerable Populations/ Kent A. Owusu, Muhammad K. Effendi, Melissa L. Thompson Bastin, Samad Tirmizi, Ishaq Lat, and Mahmoud A. Ammar, p. 575-587]
Abstract: Public health advocates and healthcare professionals (HCPs) have been challenged with vaccine hesitancy and addressing misinformation. In order for HCPs and pharmacists, in particular, to serve as effective stewards of COVID-19 vaccine science in the interest of the public good, it is imperative for HCPs to appreciate the various factors contributing to vaccine hesitancy and vaccine distrust. A PubMed search was performed and relevant articles on COVID-19 vaccine in populations of interest were included. Information from health agencies, such as the Centers for Disease Control and Prevention (CDC) as well as established professional health societies was incorporated for guidance. This review focuses on COVID-19 vaccine concerns in the populations of children, pregnancy and lactation, immunocompromised, and religious and ethnic disparities. We also discuss post emergency use authorization experience with respect to vaccine safety including annotations on Guillain-Barré Syndrome, myocarditis and pericarditis, and thrombosis with thrombocytopenia syndrome. https://doi.org/10.1177/00185787211066463