Harrold, Marc W. <br/><br/>
Basic concepts in medicinal chemistry / 
Marc W. Harrold 
 - Second edition. 
 - Bethesda, Maryland :  American Society of Civil Engineers,  c2018 
 - xii, 606 pages :  illustrations ;  26 cm. 
<br/><br/>Includes index. 
<br/><br/>Functional group characteristics and roles -- Identifying acidic and basic functional groups -- Solving pH and pKa problems -- Salts and solubility -- Drug binding interactions -- Stereochemistry and drug action -- Drug metabolism -- Structure activity relationships and basic concepts in drug design -- Whole molecule drug evaluation 
<br/><br/> Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation.  In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group. 
<br/><br/><label>ISBN: </label>9781585286010 
<br/><br/><label>Subjects--Topical Terms: </label><br/>PHARMACEUTICAL CHEMISTRY
<br/><br/><label>LC Class. No.: </label>RS 403 .H37 2018