Handbook of basic pharmacokinetics-- including clinical applications /
Wolfgang A. Ritschel
- Fourth edition.
- Hamilton, Illinois : Drug Intelligence Publications, c1992
- v, 588 pages : illustrations ; 18 cm.
Includes bibliographical references and index.
Definitions and glossary -- LADMER system-drug liberation, absorption, distribution, metabolism, elimination and response -- Organs, tissues, cells and organelles -- Cell membranes: structure, functions and properties -- Drug receptor interactions -- Absorption/transport mechanisms -- pKa and degree of ionization -- Lipid/water partition coefficient -- Physico-chemical factors altering biological performance of drugs -- Biopharmaceutical data of the gastrointestinal tract -- Fluid compartments and circulatory system (blood and lymph) -- Binding of drugs to biological material -- Drug metabolism -- Compartment models -- Determination of rate constants -- Volume of distribution and distribution coefficient -- Excretion and clearance of drugs -- Urinary and biliary recycling -- Cumulative urinary excretion -- Area under the blood level-time curve -- Pharmacokinetics of single dose administration -- Pharmacokinetics of multiple dosing -- Compartment model independent analysis -- Drug dosage in children -- Drug dosage in elderly patients -- Drug dosage in obese patients -- Drug dosage in pregnancy. (cont) Dosage regimen design -- Drug monitoring and dose adjustment -- Physiological and pathological factors influencing drug response -- First dose size in man -- Forensic pharmacokinetics -- Nonlinear pharmacokinetics -- Curve fitting -- Correlation of clinical response with drug disposition -- Bioavailability and bioequivalence -- Body surface area.
Pharmacokinetics, a comparatively young discipline among the health sciences, is interrelated with biopharmaceutics, pharmacology, and therapeutics.