Concepts in clinical pharmacokinetics /
Joseph T. DiPiro [and four others].
- Fifth edition
- Unites States of America : American Society of Civil Engineers, c2010
- xi, 248 pages : illustrations ; 27 cm
Includes index.
Introduction to pharmacokinetics and pharmacodynamics -- Basic pharmacokinetics -- Half-life, elimination rate, and AUC -- Intravenous Bolus Administration, multipe drug administration, and steady-state average concentrations -- Relationships of pharmacokinetic parameters and intravenous intermittent and continous infusions -- Two-compartment models -- Biopharmaceutics : absoption -- Drug distribution and protein binding -- Drug elimination processes -- Nonlinear processes -- Pharmacokinetic variation and model-independent relationships -- Aminoglycosides -- Vancomycin -- Theophylline -- Phenytoin and digoxin
Pharmacokinetics concepts are further illustrated by application to clinical dosing cases, including aminoglycocides, nacomycin, theophylline, digoxin, and phenytoin.