Shargel, Leon <br/><br/>
Applied biopharmaceutics and pharmacokinetics / 
Shargel Leon, Susanna Wu-Pong, and Andrew B.C. Yu 
 - Sixth edition. 
 - New Jersey :  McGraw Hill Education,  c2012 
 - vii, 811 pages :  illustrations ;  23 cm. 
<br/><br/>Includes bibliographical references and index. 
<br/><br/>Introduction to Biopharmaceutics and Pharmacokinetics -- Mathematical Fundamentals in Pharmacokinetics -- One-Compartment Open Model: Intravenous Bolus Administration -- Multicompartment Models: Intravenous Bolus Administration -- Intravenous Infusion -- Drug Elimination and Clearance -- Pharmacokinetics of Oral Absorption -- Multiple-Dosage Regimens -- Nonlinear Pharmacokinetics -- Physiologic Drug Distribution and Protein Binding -- Drug Elimination and Hepatic Clearance -- Pharmacogenetics -- Physiologic Factors Related to Drug Absorption -- Biopharmaceutic Considerations in Drug Product Design and In Vitro Drug Product Performance -- Drug Product Performance, In Vivo: Bioavailability and Bioequivalence -- Impact of Drug Product Quality and Biopharmaceutics on Clinical Efficacy -- Modified-Release Drug Products -- Targeted Drug delivery Systems and Biotechnological Products -- Relationship Between Pharmacokinetics and Pharmacodynamics -- Application of Pharmacokinetics to Clinical Situations -- Dose Adjustment in Renal and Hepatic -- Physiologic Pharmacokinetic Models, Mean Residence Time, and Statistical Moment Theory 
<br/><br/> This text integrates basic scientific principles with drug product development and clinical pharmacy practice. 
<br/><br/><label>ISBN: </label>9781259071409 
<br/><br/><label>Subjects--Topical Terms: </label><br/>BIOPHARMACEUTICS -- PHARMACOKINETICS
<br/><br/><label>LC Class. No.: </label>RM 301.4 .S53 2012