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Clinical pharmacokinetics and pharmacodynamics : concepts and applications / Malcolm Rowland and Thomas N. Tozer

By: Contributor(s): Material type: TextTextPublication details: Philadelphia, Pennsylvania : Wolters Kluwer Health/Lippincott Williams & Wilkins, c2011Edition: Fourth editionDescription: xxii, 839 pages : color illustrations ; 26 cmISBN:
  • 9780781750097
Subject(s): LOC classification:
  • RM 301.5 .R69 2011
Contents:
Therapeutic relevance -- Fundamental concepts and terminology -- Kinetics following an intravenous bolus dose -- Membranes and distribution -- Elimination -- Kinetics following an extravascular dose -- Absorption -- Response following a single dose -- Therapeutic window -- Constant-rate input -- Multiple-dose regimens -- Variability -- Genetics -- Age, weight, and gender -- Disease -- Nonlinearities -- Drug interactions -- Initiating and managing therapy -- Distribution kinetics -- Metabolites and drug response -- Protein drugs -- Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data
Summary: "Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject."--Jacket
Item type: Books
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Holdings
Item type Current library Home library Collection Call number Copy number Status Date due Barcode
Books Books National University - Manila LRC - Main General Circulation Pharmacy GC RM 301.5 .R69 2011 (Browse shelf(Opens below)) c.1 Available NULIB000000555

Includes index.

Therapeutic relevance -- Fundamental concepts and terminology -- Kinetics following an intravenous bolus dose -- Membranes and distribution -- Elimination -- Kinetics following an extravascular dose -- Absorption -- Response following a single dose -- Therapeutic window -- Constant-rate input -- Multiple-dose regimens -- Variability -- Genetics -- Age, weight, and gender -- Disease -- Nonlinearities -- Drug interactions -- Initiating and managing therapy -- Distribution kinetics -- Metabolites and drug response -- Protein drugs -- Prediction and refinement of human kinetics from in vitro, preclinical, and early clinical data

"Formerly Clinical Pharmacokinetics: Concepts and Applications, this fully updated Fourth Edition has been retitled Clinical Pharmacokinetics and Pharmacodynamics: Concepts and Applications to reflect the increasing body of knowledge linking the two concepts that explain the relationship between drug administration and drug response. This revised edition also reflects the explosion in our understanding at the molecular and mechanistic levels of all the processes controlling the pharmacokinetics of drugs. The text is authored by two leading international experts on the clinical aspects of pharmacokinetics/pharmacodynamics and is widely considered one of the authoritative texts on the subject."--Jacket

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