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Basic concepts in medicinal chemistry / Marc W. Harrold

By: Material type: TextTextPublication details: Bethesda, Maryland : American Society of Civil Engineers, c2018Edition: Second editionDescription: xii, 606 pages : illustrations ; 26 cmISBN:
  • 9781585286010
Subject(s): LOC classification:
  • RS 403 .H37 2018
Contents:
Functional group characteristics and roles -- Identifying acidic and basic functional groups -- Solving pH and pKa problems -- Salts and solubility -- Drug binding interactions -- Stereochemistry and drug action -- Drug metabolism -- Structure activity relationships and basic concepts in drug design -- Whole molecule drug evaluation
Summary: Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.
Item type: Books
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Holdings
Item type Current library Home library Collection Call number Copy number Status Date due Barcode
Books Books National University - Manila LRC - Main General Circulation Pharmacy GC RS 403 .H37 2018 (Browse shelf(Opens below)) c.1 Available NULIB000016529

Includes index.

Functional group characteristics and roles -- Identifying acidic and basic functional groups -- Solving pH and pKa problems -- Salts and solubility -- Drug binding interactions -- Stereochemistry and drug action -- Drug metabolism -- Structure activity relationships and basic concepts in drug design -- Whole molecule drug evaluation

Medicinal chemistry is a complex topic. Written in an easy to follow and conversational style, Basic Concepts in Medicinal Chemistry focuses on the fundamental concepts that govern the discipline of medicinal chemistry as well as how and why these concepts are essential to therapeutic decisions. The book emphasizes functional group analysis and the basics of drug structure evaluation. In a systematic fashion, learn how to identify and evaluate the functional groups that comprise the structure of a drug molecule and their influences on solubility, absorption, acid/base character, binding interactions, and stereochemical orientation. Relevant Phase I and Phase II metabolic transformations are also discussed for each functional group.

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