MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02548nam a2200229Ia 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
|---|
| control field |
NULRC |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
|---|
| control field |
20250520100622.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
250520s9999 xx 000 0 und d |
| 020 ## - INTERNATIONAL STANDARD BOOK NUMBER |
|---|
| International Standard Book Number |
9780748404148 |
| 040 ## - CATALOGING SOURCE |
|---|
| Transcribing agency |
NULRC |
| 050 ## - LIBRARY OF CONGRESS CALL NUMBER |
|---|
| Classification number |
RA 1191 .A43 1996 |
| 100 ## - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Aldridge, W. Norman. |
| Relator term |
author |
| 245 #0 - TITLE STATEMENT |
|---|
| Title |
Mechanisms and concepts in toxicology / |
| Statement of responsibility, etc. |
W. Norman Aldridge |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. |
|---|
| Place of publication, distribution, etc. |
London, United Kingdom : |
| Name of publisher, distributor, etc. |
Taylor & Francis, |
| Date of publication, distribution, etc. |
c1996 |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
xi, 254 pages : |
| Other physical details |
illustrations ; |
| Dimensions |
26 cm. |
| 365 ## - TRADE PRICE |
|---|
| Price amount |
USD121.05 |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references (pages 218-247) and index. |
| 505 ## - FORMATTED CONTENTS NOTE |
|---|
| Formatted contents note |
1. Scope of Toxicology -- 2. Stages in the Induction of Toxicity -- 3. Kinetics and End-points -- 4. Acute and Chronic Intoxication -- 5. Delivery of Intoxicant: Decrease in delivery to the target -- 6. Delivery of Intoxicant: Bioactivation and increase in delivery to the target -- 7. Initiating Reactions with Targets -- 8. Biological Consequences of Initiating Reactions with Targets -- 9. Exposure, Dose and Chemical Structure, Response and Activity, and Thresholds -- 10. Selective Toxicity, Animal Experimentation and In Vitro Methods -- 11. Biomonitoring -- 12. Epidemiology -- 13. Environmental and Ecotoxicology -- 14. Reflections, Research and Risk. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
An erroneous perception of risk from exposure to chemicals is that it is higher than other risks to which we are subject; it is also believed that exposure to synthetic chemicals is more hazardous than exposure to natural toxins that are present in air, water, plants and animals. This book, by clarifying the principles that apply to all chemicals and all organisms, including humans, explains why some chemicals are toxic and others are not, why different classes of chemicals cause different illnesses and why low exposures are usually harmless.The focus of Mechanisms and Concepts in Toxicology is on research procedures. Mechanistic research in toxicology leads not only to a greater understanding of the biology involved, but also the means to design substances with selectivity between species and minimal undesirable side-effects. The book develops a framework for understanding intoxication by chemicals. Five stages are described - exposure, delivery of intoxicant to its site of action, events that initiate the intoxication, early biological consequences and clinical findings. For each stage, mechanisms, concepts and keywords are defined and illustrated with examples of specific chemical intoxicants. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
TOXICOLOGY |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Library of Congress Classification |
| Koha item type |
Books |
