Applied biopharmaceutics & pharmacokinetics /
Shargel, Leon, 1941-
Applied biopharmaceutics & pharmacokinetics / Leon Shargel and Andrew B. C. Yu - Fourth edition.. - [Place of publication not identifed] : Prentice-Hall International Inc., c1999 - xiv, 768 pages : illustrations ; 26 cm.
Includes index.
Mathematical fundamentals on pharmacokinetics -- introduction to biopharmaceutics and pharmacokinetics -- one compartment model; physiological factors relating to drug absorption -- biopharmaceutic considerations in drug product design -- modified release drug products -- delivery of biotechnical products and targetted drug delivery systems -- pharmacokinetics of drug absorption -- bioavailability and bioequivalence -- multicompartmental models -- drug distribution and protein binding -- drug clearance; drug metabolism and hepatic clearance -- pharmacokinetics after intravenous infusion -- pharmacokinetics after multiple dosing -- non-linear pharmacokinetics -- introduction to clinical pharmacokinetics -- application of pharmacokinetics to clinical situations -- relationship between pharmacokinetic parameters and pharmacologic response -- physiologic pharmacokinetic model and statistical moment -- computer applications in pharmacokinetics -- biopharmaceutics and pharmacokinetic studies in drug development
This work emphasizes the application and understanding of core areas involving bioavailability, population pharmacokinetics, pharmacodynamics, metabolism and drug delivery.
838502784
BIOPHARMACEUTICS
RM 301.4 .S53 1999
Applied biopharmaceutics & pharmacokinetics / Leon Shargel and Andrew B. C. Yu - Fourth edition.. - [Place of publication not identifed] : Prentice-Hall International Inc., c1999 - xiv, 768 pages : illustrations ; 26 cm.
Includes index.
Mathematical fundamentals on pharmacokinetics -- introduction to biopharmaceutics and pharmacokinetics -- one compartment model; physiological factors relating to drug absorption -- biopharmaceutic considerations in drug product design -- modified release drug products -- delivery of biotechnical products and targetted drug delivery systems -- pharmacokinetics of drug absorption -- bioavailability and bioequivalence -- multicompartmental models -- drug distribution and protein binding -- drug clearance; drug metabolism and hepatic clearance -- pharmacokinetics after intravenous infusion -- pharmacokinetics after multiple dosing -- non-linear pharmacokinetics -- introduction to clinical pharmacokinetics -- application of pharmacokinetics to clinical situations -- relationship between pharmacokinetic parameters and pharmacologic response -- physiologic pharmacokinetic model and statistical moment -- computer applications in pharmacokinetics -- biopharmaceutics and pharmacokinetic studies in drug development
This work emphasizes the application and understanding of core areas involving bioavailability, population pharmacokinetics, pharmacodynamics, metabolism and drug delivery.
838502784
BIOPHARMACEUTICS
RM 301.4 .S53 1999